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7.3.2 Probiotics and their effects on the gut-brain axis Probiotics, defined as live microorganisms that confer health benefits when administered in adequate amounts, have gained attention as potential therapeutic agents for modulating gut microbiota and improving outcomes in diseases associated with systemic inflammation and BBB dysfunction (de LeBlanc and LeBlanc, 2014)

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The presence of two binding sites with different affinities explains the variable dose-response characteristics observed with enterostatin

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